|
rs2234693
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the haplogenotypes CTAG and CCGG of rs2234693 and rs9340799 polymorphisms could contribute significantly to the susceptibility of risk in BC positive at miscarriage and tobacco consumption in this sample population.
|
31786857 |
2020 |
|
rs9340799
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, the haplogenotypes CTAG and CCGG of rs2234693 and rs9340799 polymorphisms could contribute significantly to the susceptibility of risk in BC positive at miscarriage and tobacco consumption in this sample population.
|
31786857 |
2020 |
|
rs3778609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These SNPs were in high LD (r<sup>2</sup> > 0.9) with each other, with the top SNP, rs3778609, associated with breast cancer with an odds ratio (OR) and 95% confidence interval (95% CI) of 0.76 (0.70-0.84).
|
30642363 |
2019 |
|
rs2881766
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study suggests that polymorphisms rs2881766 and rs3020449 in estrogen receptor genes were associated with BC susceptibility as well as clinical features in Chinese women.
|
30636932 |
2019 |
|
rs200075329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that the ER S118P variant does not affect risk for breast cancer or hormone therapy resistance.
|
30560461 |
2019 |
|
rs2234693
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ESR1 rs3798577 and ESR2 rs1256049 were associated with breast cancer in ER-positive cases, and ESR1 rs2234693, and rs3798577 were associated with breast cancer in Her-2-negative cases, while the association of ESR2 rs1256049 with breast cancer was seen in Her-2 positive cases.
|
29414691 |
2018 |
|
rs3798577
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Patients carrying rs3798577 genotypes had higher risk, while rs1256049 genotype carriers had reduced risk of breast cancer.
|
29414691 |
2018 |
|
rs762292600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
AKT1 mutations (E17K) have been found in 1.4-8% of breast cancer patients.
|
29086897 |
2018 |
|
rs760503206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Surveying a small set of CAFs from breast cancer</span> biopsies, we found that a relatively common single nucleotide polymorphism, which results in the expression of a GPER variant with the amino acid substitution P16L, is associated with the nuclear localization of GPER.
|
28596490 |
2017 |
|
rs1062577
|
|
|
0.020 |
GeneticVariation |
BEFREE |
rs1062577 A allele is significantly and dramatically associated with the elevated risk and greater stages of breast cancer.
|
28216037 |
2017 |
|
rs523736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 × 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have significant associations in both discovery and validation phases.
|
27380242 |
2016 |
|
rs3798577
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Polymorphisms in ESR1 (rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls.
|
27356714 |
2016 |
|
rs1459132456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the role of this polymorphism as a risk factor for breast cancer in Kurdish patients and to investigate the possible association between Arg194Trp x-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms with clinical and histopathological outcomes of patients with breast cancer.
|
27279507 |
2016 |
|
rs2228480
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Three SNPs of the ESR1 gene, rs2077647:T>C, rs2228480:G>A and rs3798577:T>C, were not associated with increased BC risk in our overall meta-analysis.
|
27070141 |
2016 |
|
rs3798577
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The C allele of the rs3798577:T>C variant was associated with decreased BC risk in Asians (OR = 0.828, 95% CI: 0.730-0.939), while Caucasians with this allele were found to experience significantly increased BC risk (OR = 1.551, 95% CI: 1.037-2.321).
|
27070141 |
2016 |
|
rs2077647
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Rs2228480 had a large protective effect in Caucasians, while rs2077647 was not associated with BC risk.
|
27070141 |
2016 |
|
rs762292600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analysis of TCGA breast cancer data revealed that the mRNA expression, total protein levels, and phosphorylation of various RTKs are decreased in human tumors harboring AKT1(E17K).
|
27004402 |
2016 |
|
rs2881766
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the > 13-year-old group, the AA genotype at rs1062577, the GG genotype at rs2881766, and the CC genotype at rs9479118 increased breast cancer susceptibility.
|
26850117 |
2016 |
|
rs1062577
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results showed that the ESR1 rs1062577 polymorphism increased breast cancer risk in Han Chinese women, which might be used as a new SNP marker.
|
26850117 |
2016 |
|
rs9479118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the > 13-year-old group, the AA genotype at rs1062577, the GG genotype at rs2881766, and the CC genotype at rs9479118 increased breast cancer susceptibility.
|
26850117 |
2016 |
|
rs10484919
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjusting for age, body mass index, parity, and menopausal status, we found that in our cohort of 865 Malaysian Chinese, three SNPs in the 6q25.1 region near ESR1 (rs2046210, rs12173570, and rs10484919) that were associated with mammographic density, breast cancer risk, or breast size in previous GWAS were significantly associated with both percentage density and absolute dense area.
|
26677210 |
2016 |
|
rs9340799
|
|
|
0.070 |
GeneticVariation |
BEFREE |
ESR1 rs9340799(XbaI) (T>C) variants CC or TC were associated with reduced breast cancer risk (HR = 0.82,95% CI = 0.67-1.0), and ESR1 rs2077647 (T>C) variants CC or TC was associated with reduced distant recurrence risk (HR = 0.69, 95% CI = 0.53-0.90), both regardless of the treatments.
|
26590813 |
2015 |
|
rs2077647
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ESR1 rs9340799(XbaI) (T>C) variants CC or TC were associated with reduced breast cancer risk (HR = 0.82,95% CI = 0.67-1.0), and ESR1 rs2077647 (T>C) variants CC or TC was associated with reduced distant recurrence risk (HR = 0.69, 95% CI = 0.53-0.90), both regardless of the treatments.
|
26590813 |
2015 |
|
rs2234693
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the association between PvuII (rs2234693), XbaI (rs9340799) and P325P (rs1801132) polymorphisms of ESR1 gene with the risk of breast cancer under different population categorizations, we searched multiple databases for data collection, and performed the meta-analysis on a total of 25 case-control studies.
|
26434778 |
2015 |
|
rs9340799
|
|
|
0.070 |
GeneticVariation |
BEFREE |
To investigate the association between PvuII (rs2234693), XbaI (rs9340799) and P325P (rs1801132) polymorphisms of ESR1 gene with the risk of breast cancer under different population categorizations, we searched multiple databases for data collection, and performed the meta-analysis on a total of 25 case-control studies.
|
26434778 |
2015 |